The idea of pKb is used in the field of chemistry . This is a measure of basicity that is calculated from the negative logarithm ( -log ) of the basic ionization constant Kb .
It can be stated that pKb is linked to the alteration of the acid-base balance of an aqueous solution. In any case, to understand the concept , it is essential to pay attention to other notions.
The pKb , the pKa , the pH and other constants and scales refer to the acidity or alkalinity of a solution and the strength of acids and bases. When a p appears at the beginning, it indicates that this is a -log . In the case we are dealing with on this occasion, pKb is the negative logarithm of Kb .
We can establish the pKa as a magnitude that quantifies the tendency of molecules to dissociate in an aqueous solution. In the same way, it should be noted that it is established that a base is considered to be stronger the greater its pKa. On the contrary, in the case of an acid it will be stronger the lower its pKa.
Other data of interest are the following:
-Within the organic chemistry sector, we have to highlight that amines are the strongest bases. And in this case the pKb values are in the range 3-5.
-To carry out the study of acidity and basicity, it is necessary to take into account aspects such as the basicity constant Kb, the acidity constant Ka, the pKa, the pKb, the water equilibrium constant Kw, the pH and also the pOH.
pH refers specifically to the concentration of hydrogen ions . A solution can be neutral ( pH equal to 7 ), alkaline ( pH greater than 7 ) or acidic ( pH less than 7 ).
The dissociation constant of the base is Kb , just as the dissociation constant of the acid is Ka . It can be said, in this framework, that Kb reveals the extent to which the base dissociates into its ions.
In turn, pKb is the -log or negative logarithm of Kb (the dissociation constant of the base). A reduced pKb is associated with a strong base, while a large pKb reveals a weak base. The opposite occurs with Kb : the higher Kb , the greater the strength of the base (higher level of dissociation) and vice versa.
From all of the above, we can also add that, from the pKa of an acid, we can proceed to discover what the pKb of its conjugate base is and vice versa.
PKB (all capital letters), finally, is the acronym that corresponds to protein kinase B or, in our language, protein kinase B.
We can establish that the aforementioned protein kinase B can be of three fundamental types:
-AKT1, which plays a fundamental role in cell survival and is related to different types of cancer.
-AKT2, which is related to the insulin signaling pathway.
-The AKT3.